Car-Therapy protects a girl in the world for the first time in La Pause Hospital with a rare autoimmune disease | Science
Anti-MD5 dermatomyositis is a rare disease that affects a person’s immunity to every million inhabitants. It is characterized by provoking rapid damage to Lung pyramids, which ends life between 30 and 66% of patients, and there are no specific treatments to deal with it. Now, the La Pause University HospitalIn Madrid, she successfully treated the girl with the disease using her car-therapy, which was first achieved worldwide. The case has been published Medical magazine With.
Car-thex treatments They are a kind of personalized immunotherapy, which is very successful in the treatment of cancer, mainly in blood tumors such as some leukemia or lymphomas, as the last attempt, when other treatments fail. Its action is to modify the patient’s t lymphocytes (a kind of white blood cells) to identify and destroy cancer cells. First, patient cells are captured and then genetically modified in the laboratory to express a specific recipient (CAR) against tumor antigen. They multiply and inject the patient again. In the case of autoimmune disease, T lymphocytes are modified to detect CD 19 protein, which appears in B lymphocytes, including the keys in the development of many diseases, including dermatomyositis.
Peace patient is treated with CD19 car-T treatment, specifically, sophisticated cell therapy ARI -0001 Built the Clinic Hospital in Barcelona. This initiative has been able to make a medicine more affordable to cost hundreds of thousands of euros and has not been used for autoimmune disease such as MD Anti-MD5 dermatomyositis. Treatment was able to rebuild a part of the immune system, allowed the patient to be inactive without the need for other treatments.
Treatment is administered by compassionate use depending on the patient’s clinical condition. After the administration of medication, the girl did not go without treatment to reduce immunity of more than 10 lines and now it has been relieving the disease for a year. The motor condition, along with this illness, gradually improves and inhale the daytime HE due to mechanical ventilation and ECMO from breathing and ECMO.
Like other autoimmune diseases, it is a long -term question of corticosteroids, immunosuppressants, biological agents and the general combination of chemotherapy. The use of a combination of these treatments has risks such as standards and increased risk of infections. But, despite many treatments, patients saved in La Paz are usually not good response, which describes the high deaths of the disease.
Since they started applying in 2011, Car-T had achieved ten thousand people Full remedies In those with blood tumors, but in recent years they have also shown their influence in autoimmune diseases. In 2022, these treatments were applied to people with systemic lupus erythematosus, which was an autoimmune illness, which achieved 0.1%of the world’s population, especially young women, Full referrals. Excellent results are also found in patients with severe myaster. For a 33-year-old patient, a machine requires a machine to move due to progressive paralysis, received some car-ti, and he re-mobilized the electric bicycle and improved to make more than 25 km.
For the future, CAR-T can be used before multiple sclerosis. In the clinic, the disease is in progress to test whether this immunotherapy is useful, and is more complicated than others who have already been treated for this technology.
Today’s success submitted by the University of Law Pause is thanks to the collaboration of a large number of toilets from the various specialties of the hospital and the cooperation of other organizations such as CRIS, the National Center for Oncological Research (CNIO) or other organizations.
