Liver disease that can be shot after menopause arrives

Over time and from 50 Women begin to experience symptoms such as suffocation, night sweating, muscle mass loss, BoneWhich can lead to osteoporosis … There are different effects that may occur during this stage, which can even Increase the risk of some diseasesDue to low estrogen levels. Hepatic diseases are an example, specifically, we are talking about cirrhosis, a condition that can occur according to Spanish experts after fibrosis.

Researchers from the Institute of German Research, Trias I (IGTP), led a study published in the magazine Laboratory animals This resides, for the first time, the gender difference against liver disease in an advanced stage in the mice model. Specialists analyzed two types of liver disease It is frequently presented in women with menopause. Discover what its symptoms are and what is the effect of this diseases in the peak stage.

How does menopause affect the liver?

Justina Faber

The group of researchers showed that liver diseases differ in their development and development between men and women. It seems that the estrogen hormone plays a preventive roleSo women will have some protection for the development of the disease. This directly affects menopause, since then During this stage, estrogen levels decrease, among other thingsTherefore, menopausal women have more irrigation of liver disease.

In fact, and Menopause Institute He expressed that according to a study conducted in Energy and nutrition metabolism set From UIB (Balearic Islands University) that was implemented in mice and in the laboratory, estrogen provides a wide range of preventive effects in the liver. This is greatly associated with improving mitochondria function and regulating fats in liver cells. For this reason, “Increases the risk of liver disease after menopause arrivesAccording to the above -mentioned study, gender differences were observed in both humans and animal models used in pre -clinical studies.

However, most research in mice and rats did not take into account these differences and have been done only in males. Studies on cirrhosis that both sexes used They focused on the role of sex hormones In the early stages of its progress, leaving the liver fibrosis. In another study, the effect of sex on the cirrhosis model was determined with climbing in mice that was described only for males.

In this way, liver fibrosis in animals by giving, over and over, caused the fourth carbon chloride and adjusting its doses until the appearance of dropsy. The response of males and females was different. “Males developed dropsy at a time provided by the model, while females not only did this by increasing doses more and taking twice as much as experts.

What is fibrosis and cirrhosis?

Ferbik

Output Various differences between fibrosis and cirrhosis. To determine what fibrosis is according to IGTP professionals, we must know that when a member is infected, the body begins to heal. If the lesion is repeated or chronic, this may lead to excessive accumulation of fibrous tissues and causes changes in the structure of the affected organ. This phenomenon is known as fibrosis.

Cirrhosis can affect organs such as kidneys, lungs, heart and liver. For the latter, advanced fibrosis It can develop towards cirrhosisThe latest and most irreversible stage of liver disease, where secondary complications such as dropsy, the accumulation of liquid in the abdomen are provided.

They also indicate from participating before National Institute for Diabetes and Diseases of the Digestive and kidney system Liver fibrosis is a condition in which the liver heals and permanently damaged. The tissue of the scar is replaced by the healthy liver tissues and prevents the liver from working normally. Nudious tissue also prevents blood flow in part throughout the liver. With increasing cirrhosis, the liver begins to fail.

Many people do not know that they have liver fibrosis, because they may not have any sign or symptoms until their liver is seriously damaged. For this reason, it is necessary to determine what it is and be able to identify it in time to stop this disease as soon as possible. The first effects are manifested According to experts, they are:

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Reference

Iborra I, Bartoli R, Bargalló A, et al. The effect of sexual differences on the incitement and development of clinical signs of the mice model for the final liver disease. Laboratory animals. 2025. Di:10.1177/00236772241309760