Children’s exposure to toxins can explain the increase in colon and rectal cancer between younger
According to a new study, Childhood exhibition to bacterial poison The product in the intestine can cause Increase in colon and rectal cancer Among the youth.
The results are the last evidence of what causes a global increase in early appearance cancers. Although before looking at it Aging diseaseScientists rushed to understand the reason for the existence of more and more people under the age of 50 and who suffer from cancer.
According to the 2023 studyThe number of diagnoses of early appearance cancer It has increased all over the world by 80 % since 1990While deaths increased by 28 %. Prostate cancers The nasopharynx, or related to the throat, is the one that witnessed the largest increase in cases of injury.
It is not completely clear, but researchers believe that the bounce is due to a mixture of Environmental factors and lifestyle This leads to mutations in our genes, which increases the risk of suffering certain types of cancer.
New analysis, Posted in “Nature” magazineIt indicates that in the case of colon and rectal cancer, the response is partially in the child’s exposure to bacterial toxins called Colibactin. Colibactin is produced by a specific strain of E. Coli, which is a common intestinal intestinal microe.
The exhibition in early childhood It appears to leave a unique genetic sign on colon cellsWhich increases the risk of colon and rectal cancer before the age of 50, according to the study.
Genetic mutations related to collabactein
“These mutations are a kind of historical record in the genome and indicate that exposure to chocctin in the early years of life It is a decisive factor for the early appearance of the disease“Ludmil Alexandrov, the main author of the study and professor of cellular and molecular medicine at the University of California, San Diego, in a statement.
The researchers analyzed samples of 981 colon cancer patients from 11 countries. Discover that The genetic mutations associated with Colbs have been 3.3 times more repeated in cancer patients at the age of 40. From those who were diagnosed after 70 years. In countries where colon and rectal cancer was more common, the mutations were more frequent, according to the study.
In particular, genetic changes emerged soon, with the growth of tumors, in line with the previous investigations that indicate this Mutations occur in the first ten years of life. According to researchers, this means that bacteria can bring the Earth to cancer in young children, decades before symptoms.
“This changes our way of thinking about cancer,” Alexanderov says. “It may not be what happens only in adulthood, however Cancer can be affected by the events that occurred in the early years of lifePerhaps even in the early years. “
Study restrictions
Independent experts indicated this More studies are needed To confirm this Colibactin associated mutations cause color cancerAs well as the way children are exposed to bacteria.
“It is not clear when and how this intestine reaches this intestine Coli Concrete E.There is no cause of disappearance usually when cancer begins to grow. “
There are also doubts about how to eliminate bacteria and if It can have unwanted consequences for the health of the intestineHe added that E. Coli bacteria are used in some probiotics. He said that many people can be exposed to collabakin without contracting cancer.
“I think it is very likely that cancer will occur in some cases only, because although someone can have” bad mistakes “that cause mutations, these errors must cause Sufficient mutations for cancer transplantationGraham said.
